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Test Code ARBI Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum

Reporting Name

ACh Receptor (Muscle) Binding Ab

Useful For

Supporting the diagnosis of autoimmune myasthenia gravis (MG) in adults and children

 

Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders

 

An adjunct to the test for P/Q-type calcium channel binding antibodies as a diagnostic aid for Lambert-Eaton myasthenic syndrome

Testing Algorithm

This is the primary diagnostic test for myasthenia gravis.

 

For information see:

Myasthenia Gravis Evaluation with MuSK Reflex Algorithm

Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Ordering Guidance


For the initial diagnostic workup of patients with suspicion of myasthenia gravis, one of the following testing algorithms is recommended:

-Myasthenia Gravis Evaluation with MuSK Reflex Algorithm

-Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm

 

Standalone testing ARBI / Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum is recommended in certain situations.

 

This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held for 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.



Specimen Required


Patient Preparation: For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication.

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

≤0.02 nmol/L

Day(s) Performed

Monday through Sunday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83519

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ARBI ACh Receptor (Muscle) Binding Ab 97558-1

 

Result ID Test Result Name Result LOINC Value
8338 ACh Receptor (Muscle) Binding Ab 97558-1

Report Available

3 to 6 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Method Name

Radioimmunoassay (RIA)

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.