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HelpTest Code BNZU Benzodiazepines Confirmation, Random, Urine
Advisory Information
1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order BNZX / Benzodiazepines Confirmation, Chain of Custody, Random, Urine.
2. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Random, Urine.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. No STATS are accepted for this procedure.
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
Secondary ID
608255Useful For
Detecting drug use involving benzodiazepines such as alprazolam, chlordiazepoxide, clonazepam, diazepam, midazolam, oxazepam, temazepam, clobazam, flunitrazepam, flurazepam, lorazepam, prazepam, triazolam, and zolpidem
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Benzodiazepines Confirmation, USpecimen Type
UrineSpecimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross icterus | Reject |
Reference Values
Negative
Cutoff concentrations:
Alprazolam by LC-MS/MS: 10 ng/mL
Alpha-Hydroxyalprazolam by LC-MS/MS: 10 ng/mL
Chlordiazepoxide by LC-MS/MS: 10 ng/mL
Clonazepam by LC-MS/MS: 10 ng/mL
7-Aminoclonazepam by LC-MS/MS: 10 ng/mL
Diazepam by LC-MS/MS: 10 ng/mL
Nordiazepam by LC-MS/MS: 10 ng/mL
Midazolam by LC-MS/MS: 10 ng/mL
Alpha-Hydroxy Midazolam by LC-MS/MS: 10 ng/mL
Oxazepam by LC-MS/MS: 10 ng/mL
Temazepam by LC-MS/MS: 10 ng/mL
Clobazam by LC-MS/MS: 10 ng/mL
N-Desmethylclobazam by LC-MS/MS: 10 ng/mL
Flunitrazepam by LC-MS/MS: 10 ng/mL
7-Aminoflunitrazepam by LC-MS/MS: 10 ng/mL
Flurazepam by LC-MS/MS: 10 ng/mL
2-Hydroxy Ethyl Flurazepam by LC-MS/MS: 10 ng/mL
Lorazepam by LC-MS/MS: 10 ng/mL
Prazepam by LC-MS/MS: 10 ng/mL
Triazolam by LC-MS/MS: 10 ng/mL
Alpha-Hydroxy Triazolam by LC-MS/MS: 10 ng/mL
Zolpidem by LC-MS/MS: 10 ng/mL
Zolpidem Phenyl-4-Carboxylic acid by LC-MS/MS: 10 ng/mL
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80347
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BNZU | Benzodiazepines Confirmation, U | 90890-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 608256 | Alprazolam by LC-MS/MS | 59615-5 |
| 608257 | Alpha-Hydroxyalprazolam by LC-MS/MS | 16348-5 |
| 608258 | Chlordiazepoxide by LC-MS/MS | 20522-9 |
| 608259 | Clonazepam by LC-MS/MS | 16229-7 |
| 608260 | 7-aminoclonazepam by LC-MS/MS | 51776-3 |
| 608261 | Diazepam by LC-MS/MS | 16227-1 |
| 608262 | Nordiazepam by LC-MS/MS | 16228-9 |
| 608263 | Midazolam by LC-MS/MS | 16233-9 |
| 608264 | Alpha-Hydroxy Midazolam by LC-MS/MS | 59590-0 |
| 608265 | Oxazepam by LC-MS/MS | 16201-6 |
| 608266 | Temazepam by LC-MS/MS | 20559-1 |
| 608267 | Clobazam by LC-MS/MS | 59635-3 |
| 608268 | N-Desmethylclobazam by LC-MS/MS | In Process |
| 608269 | Flunitrazepam by LC-MS/MS | 20528-6 |
| 608270 | 7-aminoflunitrazepam by LC-MS/MS | 51777-1 |
| 608271 | Flurazepam by LC-MS/MS | 16231-3 |
| 608272 | 2-Hydroxy Ethyl Flurazepam by LC-MS/MS | In Process |
| 608273 | Lorazepam by LC-MS/MS | 17088-6 |
| 608274 | Prazepam by LC-MS/MS | 17479-7 |
| 608275 | Triazolam by LC-MS/MS | 16232-1 |
| 608276 | Alpha-Hydroxy Triazolam by LC-MS/MS | 49876-6 |
| 608277 | Zolpidem by LC-MS/MS | 72770-1 |
| 608278 | Zolpidem Phenyl-4-Carboxylic acid by LC-MS/MS | 72768-5 |
| 608448 | Benzodiazepines Interpretation | 16195-0 |