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Test Code FYABS Yo Antibody Screen with Reflex to Titer and Western Blot

Specimen Required

Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 0.5 mL of serum ambient in a plastic vial.


Note: Overnight fasting is preferred.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FYABW Yo Ab, Western Blot No No
FYABT Yo Ab Titer No No

Testing Algorithm

If Yo Antibody Screen, IFA is positive, Yo Ab, Western Blot, FYABW, will be performed at an additional charge.

If Yo Antibody, Western Blot is positive, Yo Ab Titer, FYABT, will be performed at an additional charge.

Method Name

Immunofluorescence Assay (IFA)

Western Blot (WB)

Reporting Name

Yo Ab Scr. w/Reflex to Titer and WB

Specimen Type


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Ambient (preferred) 7 days
  Frozen  21 days
  Refrigerated  14 days

Reject Due To

Hemolysis Mild OK; Gross reject
Lipemia Mild reject; Gross reject
Icterus Mild OK; Gross reject
Other NA

Reference Values

Yo Ab, IFA:       Negative


Purkinje cells cytoplasmic antibody (Yo) can be found in approximately 50% of patients with paraneoplastic cerebellar degeneration (PCD). The presence of Yo antibody strongly suggests underlying gynecological cancer primarily of ovarian or breast origin. A negative assay for Yo antibody does not exclude the possibility of a malignant tumor.

Day(s) Performed

Monday, Wednesday, Friday

Report Available

4 to 12 days

Performing Laboratory

Quest Diagnostics Nichols Institute

Test Classification

This test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

CPT Code Information


84181-Western Blot with interpretation and report (if appropriate)

86256-Titer, each antibody (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FYABS Yo Ab Scr. w/Reflex to Titer and WB 14249-7


Result ID Test Result Name Result LOINC Value
Z3692 Yo Ab, IFA 14249-7