Home
HelpTest Code SHBG Sex Hormone-Binding Globulin (SHBG), Serum
Reporting Name
Sex Hormone Binding Globulin, SUseful For
Diagnosis and follow-up of women with symptoms or signs of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism)
An adjunct in monitoring sex-steroid and anti-androgen therapy
An adjunct in the diagnosis of disorders of puberty
An adjunct in the diagnosis and follow-up of anorexia nervosa
An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)
A possible adjunct in diagnosis and follow-up of insulin resistance and cardiovascular and type 2 diabetes risk assessment, particularly in women
In laboratories without access to bioavailable testosterone or equilibrium dialysis-based "true" free testosterone assays, sex hormone-binding globulin measurement is crucial in cases when assessment of the free testosterone fraction (aka free androgen index or calculated free testosterone) is required. At Mayo Clinic Laboratories, both bioavailable testosterone (TTBS / Testosterone, Total and Bioavailable, Serum) and free testosterone (TGRP / Testosterone, Total and Free, Serum) measurements are available. Free testosterone (TGRP) is measured by equilibrium dialysis, obviating the need for sex hormone-binding globulin measurements to calculate free androgen fractions.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 60 days |
Reference Values
CHILDREN
Males
|
Tanner Stages* |
Mean Age |
Reference Range (nmol/L) |
|
Stage I |
7.1 |
31-167 |
|
Stage II |
11.5 |
49-179 |
|
Stage III |
13.6 |
5.8-182 |
|
Stage IV |
15.1 |
14-98 |
|
Stage V |
18.0 |
10-57 |
*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±2) years. For boys, there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.
Females
|
Tanner Stages* |
Mean Age |
Reference Range (nmol/L) |
|
Stage I |
7.1 |
43-197 |
|
Stage II |
10.5 |
7.7-119 |
|
Stage III |
11.6 |
31-191 |
|
Stage IV |
12.3 |
31-166 |
|
Stage V |
14.5 |
18-144 |
*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.
ADULTS
Males: 10-57 nmol/L
Females (non-pregnant): 18-144 nmol/L
Day(s) and Time(s) Performed
Monday through Friday; 5 a.m.-3 p.m.
Saturday; 6 a.m.-3 p.m.
Test Classification
This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
84270
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SHBG | Sex Hormone Binding Globulin, S | 13967-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SHBG | Sex Hormone Binding Globulin, S | 13967-5 |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
Method Name
Automated Chemiluminescent Immunometric Assay